abstract：:Apoptosis is a form of cellular suicide and is activated in various cells, including keratinocytes, in response to physiological and pathological stimuli. A current hypothesis holds that apoptotic cells in a concerted manner express characteristic phenotypic features comprising cytoplasmic budding, pyknosis, chromatin...

journal_title：Acta dermato-venereologica

authors： Gniadecki R,Gajkowska B,Bartosik J,Hansen M,Wulf HC

更新日期：1998-07-01 00:00:00

abstract：:The Thomsen-Friedenreich (T) antigen is the core disaccharide of cancer-associated carbohydrates, whose expression allegedly correlates with the prognosis of some carcinomas. We studied the expression of the T antigen and its precursor (Tn) with monoclonal antibodies in formalin-fixed specimens of normal skin and vari...

journal_title：Acta dermato-venereologica

authors： Kanitakis J,al-Rifai I,Faure M,Claudy A

更新日期：1998-05-01 00:00:00

abstract：:Eye colour, hair colour and skin colour are important risk factors for malignant melanoma and non-melanoma skin cancers. There are few studies in which the distribution of these pigmentary factors in risk populations has been assessed. The purpose of this study was to investigate the prevalence of the major eye and ha...

journal_title：Acta dermato-venereologica

authors： Lock-Andersen J,Wulf HC,Knudstorp ND

更新日期：1998-05-01 00:00:00

abstract：:Retinol and proguanil are metabolised by the same family of hepatic cytochrome P450, i.e. CYP2C. We used proguanil as a probe to study CYP2C activity, and by implication retinol metabolism, in psoriasis. In vitro studies showed that retinol competitively inhibited the hepatic metabolism of proguanil to cycloguanil. Pr...

journal_title：Acta dermato-venereologica

authors： Helsby NA,Ward SA,Parslew RA,Friedmann PS,Rhodes LE

更新日期：1998-03-01 00:00:00

abstract：:Having observed altered itch and flare reactions after histamine application in patients with atopic eczema, we tried to determine these reactions in patients with urticaria and psoriasis. We investigated 16 healthy non-atopic subjects, 16 atopics in an eczema-free interval, 16 with acute atopic eczema, 16 with urtica...

journal_title：Acta dermato-venereologica

authors： Heyer G,Koppert W,Martus P,Handwerker HO

更新日期：1998-03-01 00:00:00

abstract：:Endoglin is a glycoprotein which is predominantly expressed on endothelial cells. It is upregulated under inflammatory conditions as well as in skin lesions where endothelial cell proliferation occurs. Endoglin has the capacity to bind transforming growth factor beta (TGF-beta) and can reduce the bioavailability of TG...

journal_title：Acta dermato-venereologica

authors： van de Kerkhof PC,Rulo HF,van Pelt JP,van Vlijmen-Willems IM,De Jong EM

更新日期：1998-01-01 00:00:00

abstract：:Two cases of subacute cutaneous lupus erythematosus are described. Features which delayed diagnosis are discussed. The potential clinical and histopathological overlap between this condition and erythema multiforme is emphasized, drawing attention to the histological features which allow distinction. The possibility t...

journal_title：Acta dermato-venereologica

authors： Lyon CC,Blewitt R,Harrison PV

更新日期：1998-01-01 00:00:00

abstract：:The incidence of refractory atopic dermatitis has increased in teenagers and young adults. The purpose of this study was to control the skin symptoms of such patients in daily life. Seventy patients repeatedly took a 10-min 42 degrees C acidic hot-spring bath twice daily. The skin symptoms were improved in 76% of case...

journal_title：Acta dermato-venereologica

authors： Kubota K,Machida I,Tamura K,Take H,Kurabayashi H,Akiba T,Tamura J

更新日期：1997-11-01 00:00:00

abstract：:Patients with rheumatoid arthritis were investigated for contact allergy to gold in connection with treatment with gold preparations. There were 57 patients with rheumatoid arthritis previously treated with gold, with or without cutaneous side-effects, as well as 20 patients intended for such treatment; all were expos...

journal_title：Acta dermato-venereologica

authors： Möller H,Svensson A,Björkner B,Bruze M,Lindroth Y,Manthorpe R,Theander J

更新日期：1997-09-01 00:00:00

abstract：:Ciprofloxacin (CPFX) is a widely used fluoroquinolone antibiotic, inducing cutaneous adverse drug reactions in about 1 to 2% of the treated patients. Conclusive diagnosis of drug allergy, however, still remains a major problem in daily clinical practice. Here, we present 2 patients with drug allergy to CPFX. In both c...

journal_title：Acta dermato-venereologica

authors： Rönnau AC,Sachs B,von Schmiedeberg S,Hunzelmann N,Ruzicka T,Gleichmann E,Schuppe HC

更新日期：1997-07-01 00:00:00

abstract：:Vulvar vestibulitis, as defined by Friedrich, is considered to be inflammatory, despite the fact that the normal histology of this specific area has previously not been characterized. The aim of the present study was to compare the normal histology of the vulvar vestibulum with findings in localized vulvar vestibuliti...

journal_title：Acta dermato-venereologica

authors： Lundqvist EN,Hofer PA,Olofsson JI,Sjöberg I

更新日期：1997-07-01 00:00:00

abstract：:The aim of this study, was to observe the effects of KH-1060, a new vitamin D3 analogue, on the dermis of hairless mice by electron microscopy. KH-1060 (0.2 micrograms/ml in isopropanol) or KH-1060 following betamethasone 17-valerate (2 mg/ml in isopropanol) was applied topically to the backs of hairless mice for 4 we...

journal_title：Acta dermato-venereologica

authors： Kobayasi T

更新日期：1997-05-01 00:00:00

abstract：:Squamous cell carcinomas (SCC) are the most frequent tumours complicating organ transplantation. Whereas most SCC can be successfully treated with conventional surgery, other lesions show an aggressive course with recurrence and metastases. We assessed the value of nuclear morphometry in detecting tumours with an ab i...

journal_title：Acta dermato-venereologica

authors： Narvaez D,Kanitakis J,Euvrard S,Schmitt D,Faure M,Claudy A

更新日期：1997-03-01 00:00:00

abstract：:The aim of the present study was to investigate the relationship between patients' own recognition of skin problems using consumer products and the results of patch testing with markers of fragrance sensitization. Eight hundred and eighty-four consecutive eczema patients, 18-69 years of age, filled in a questionnaire ...

journal_title：Acta dermato-venereologica

authors： Johansen JD,Andersen TF,Veien N,Avnstorp C,Andersen KE,Menné T

更新日期：1997-03-01 00:00:00

abstract：:Although atopic dermatitis is a skin disorder, it includes immune deviations such as T-cell accumulation and activation in the skin, resulting in chronic, relapsing eczema. The T-lymphocyte activation in the skin is not accompanied by specific allergies in up to two thirds of the patients. It has been shown that T-cel...

journal_title：Acta dermato-venereologica

authors： Thestrup-Pedersen K,Ellingsen AR,Olesen AB,Lund M,Kaltoft K

更新日期：1997-01-01 00:00:00

abstract：:In a randomized, controlled parallel group study we have shown that cyclosporine at 3 mg/kg/day is as effective as topical betamethasone-17,21-dipropionate in the treatment of chronic hand eczema. In this study we compared the influence of these therapies on the quality of life. Forty-one patients were treated with ei...

journal_title：Acta dermato-venereologica

authors： Granlund H,Erkko P,Reitamo S

更新日期：1997-01-01 00:00:00

abstract：:Abnormal expression of cell adhesion molecules and related proteins has been observed in various carcinoma cells. We compared expression patterns of desmosomal cadherins, E-cadherin, and cytoplasmic plaque proteins of four different human squamous cell carcinoma cell lines and in vivo squamous cell carcinoma cells wit...

journal_title：Acta dermato-venereologica

authors： Harada H,Iwatsuki K,Ohtsuka M,Han GW,Kaneko F

更新日期：1996-11-01 00:00:00

abstract：:We report on a 44-year-old patient with erythropoietic protoporphyria who could effectively control his photosensitivity for 22 years with oral carotinoids. The clinical course of his disorder was complicated by liver involvement, initially expressed as marginally raised serum transaminase levels for several years. Te...

journal_title：Acta dermato-venereologica

authors： Bruch-Gerharz D,Bolsen K,Gerharz CD,Goerz G

更新日期：1996-11-01 00:00:00

abstract：:The burning mouth syndrome is characterized by an unpleasant sensation of burning in the oral cavity, without clinical signs. Causal factors may be psychogenic, systemic or local. The aim of the study was to determine the significance of contact allergy in the pathogenesis of burning mouth syndrome. Fifteen patients w...

journal_title：Acta dermato-venereologica

authors： Virgili A,Corazza M,Trombelli L,Arcidiacono A

更新日期：1996-11-01 00:00:00

abstract：:Urinary excretion of glycosaminoglycans was measured in 10 patients with pretibial myxoedema, 7 of whom also had thyroid-associated ophthalmopathy, and in 3 additional patients with ophthalmopathy but no skin changes. Total uronic acid excretion was raised above control levels in only 2 patients, who had both eye and ...

journal_title：Acta dermato-venereologica

authors： Priestley GC,Aldridge RD,Hurel S

更新日期：1996-09-01 00:00:00

abstract：:Considerable interest has been recently generated concerning the use of natural compounds, anti-oxidants in particular, in photoprotection. Two of the best known anti-oxidants are vitamins C and E, both of which have been shown to be somewhat effective in different models of photodamage. Very little has been reported,...

journal_title：Acta dermato-venereologica

authors： Darr D,Dunston S,Faust H,Pinnell S

更新日期：1996-07-01 00:00:00

abstract：:Patients with clinical features of dorsal macular amyloidosis but without subepidermal amyloid deposits were followed for 2-11 years. The clinical appearance was fairly stable during this period of time, with little tendency of healing. Only 2 of the patients developed typical macular amyloidosis during the follow-up....

journal_title：Acta dermato-venereologica

authors： Westermark P,Ridderström E,Vahlquist A

更新日期：1996-07-01 00:00:00

abstract：:Mast cells are thought to be involved in neurogenic inflammation in skin, and numerous neuropeptides are known to degranulate mast cells. We monitored histamine release in skin in situ with the microdialysis method after skin challenge with neuropeptide injections (10 microM substance P, vasoactive intestinal peptide ...

journal_title：Acta dermato-venereologica

authors： Huttunen M,Harvima IT,Ackermann L,Harvima RJ,Naukkarinen A,Horsmanheimo M

更新日期：1996-05-01 00:00:00

abstract：:Neuromediators may influence the immune response. To investigate their potential immunomodulating role in established allergic contact dermatitis in man, the following neuromediators were tested: vasoactive intestinal polypeptide (VIP), serotonin, and the serotonin antagonists ketanserin, methiotepine and ICS-205-930....

journal_title：Acta dermato-venereologica

authors： Bondesson L,Nordlind K,Mutt V,Lidén S

更新日期：1996-03-01 00:00:00

abstract：:We report a 69-year-old man with severe generalized morphea, who showed over 80% of skin involvement, while the internal organs were not affected. We performed histological examinations and analysis of skin disaccharides constituting chondroitinase-digestible glycosaminoglycans in the center and periphery of the scler...

journal_title：Acta dermato-venereologica

authors： Akimoto S,Ishikawa O,Yokoyama Y,Amano H,Miyachi Y

更新日期：1996-03-01 00:00:00

abstract：:The aromatic retinoids etretinate and acitretin are widely used in the systemic treatment of severe psoriasis. The purpose of the present investigation was to further elucidate the mode of action of acitretin on abnormal keratinization and epidermal hyperproliferation in an in vivo model. Studies on the interference o...

journal_title：Acta dermato-venereologica

authors： Gerritsen MJ,van Pelt JP,van de Kerkhof PC

更新日期：1996-01-01 00:00:00

abstract：:A 78-year-old man is described, who over 18 years developed three different types of keratoacanthoma: multiple keratoacanthomas, keratoacanthoma centrifugum marginatum and giant keratoacanthoma. Histological examination of the different neoplasms showed similar changes, all typical of a keratoacanthoma. In situ hybrid...

journal_title：Acta dermato-venereologica

authors： Schaller M,Korting HC,Wolff H,Schirren CG,Burgdorf W

更新日期：1996-01-01 00:00:00

abstract：:Eight out of 30 consecutive patients with AIDS and cryptococcal meningoencephalitis (26,7%) presented cutaneous involvement, in the form of papulo-nodular lesions in 3 patients, molluscum contagiosum-like lesions in 3 patients, and pustular-ulcerative lesions in 2 patients. Skin localization represented an untoward pr...

journal_title：Acta dermato-venereologica

authors： Manfredi R,Mazzoni A,Nanetti A,Mastroianni A,Coronado O,Chiodo F

更新日期：1996-01-01 00:00:00

abstract：:In order to find image descriptors enabling the characterization of sclerotic skin of morphea plaques and their objective differentiation from normal skin, we studied 52 lesions in 35 patients affected by plaque type morphea. Echographic evaluations were carried out using a 20 MHz B-scanner, providing cross-sectional ...

journal_title：Acta dermato-venereologica

authors： Seidenari S,Conti A,Pepe P,Giannetti A

更新日期：1995-11-01 00:00:00

abstract：:We have analyzed 8 patients (6 men and 2 women, aged 52 to 70 years) with psoriasis associated with hepatitis C virus (HCV) infection among 79 psoriatic patients. Psoriasis preceded in 6 cases. One patient had generalized pustular psoriasis (GPP), and the others had psoriasis vulgaris (PV). The psoriasis area and seve...

journal_title：Acta dermato-venereologica

authors： Yamamoto T,Katayama I,Nishioka K

更新日期：1995-11-01 00:00:00

abstract：:Patients with atopic dermatitis were found to have an about 7-fold increased spontaneous proliferative response of peripheral blood lymphocytes and an about 4-fold elevation of CD3-dependent lymphocyte transformation as compared to normal controls. The CD3-dependent lymphocyte response in patients with severe atopic d...

journal_title：Acta dermato-venereologica

authors： Glinski W,Stepien-Sopniewska B,Korczak-Kowalska G,Glinska-Ferenz M,Gorski A

更新日期：1995-09-01 00:00:00

abstract：:Scalp psoriasis is associated with hair loss and an increased telogen/anagen ratio. Topical treatment of scalp psoriasis (with corticosteroids, dithranol or tar) results in decreased scaling, induration and erythema of the plaques. Calcipotriol is effective in the treatment of psoriasis vulgaris. However, the potent g...

journal_title：Acta dermato-venereologica

authors： Kuijpers AL,van Baar HM,van Gasselt MW,van de Kerkhof PC

更新日期：1995-09-01 00:00:00

abstract：:The antimalarial drug chloroquine is also used in the prevention of photodermatoses and in patients with inflammatory connective diseases. The drug binds strongly to melanin. Melanocytic activity can be studied by analysis of the urinary markers of eumelanin (6-hydroxy-5-methoxyindole-2-carboxylic acid, 6H5MI-2-C) and...

journal_title：Acta dermato-venereologica

authors： Sjölin-Forsberg G,Hansson C,Kågedal B,Gannedahl EL,Berne B

更新日期：1995-07-01 00:00:00

abstract：:The expression of the transglutaminase I in human anagen hair follicles was studied by an immunohistochemical staining. In the bulbar and suprabulbar portions of anagen hair follicles, transglutaminase I was detected on the hair cuticle and the three layers of the inner root sheath. Subsequently, the positive staining...

journal_title：Acta dermato-venereologica

authors： Tamada Y,Takama H,Kitamura T,Ikeya T,Yokochi T

更新日期：1995-05-01 00:00:00

abstract：:Patients with X-linked recessive ichthyosis (RXLI) were studied as a model of the effect of disturbed epidermal lipid composition on skin barrier function. Thirteen patients with RXLI and 15 age- and sex-matched controls were patch-tested with sodium lauryl sulphate (SLS) 0.5% for 24 h. Basal skin properties and skin ...

journal_title：Acta dermato-venereologica

authors： Johansen JD,Ramsing D,Vejlsgaard G,Agner T

更新日期：1995-05-01 00:00:00

abstract：:Significant cutaneous vascular IgA deposits are common in Henoch-Schönlein purpura but not in other vasculitides. The specificity for IgA vascular deposits for Henoch-Schönlein purpura is not well defined. To examine the specificity of IgA vascular deposits for this disease, we compared clinicopathologic features of 9...

journal_title：Acta dermato-venereologica

authors： Helander SD,De Castro FR,Gibson LE

更新日期：1995-03-01 00:00:00

abstract：:Zinc therapies exert beneficial effects in several cutaneous pathologies through their antiinflammatory properties, but target cells and mechanisms of action are still uncertain. We wondered whether markers of the keratinocyte activation state, such as the expression of immune surface antigens (ICAM-1 and HLA-DR) and ...

journal_title：Acta dermato-venereologica

authors： Guéniche A,Viac J,Lizard G,Charveron M,Schmitt D

更新日期：1995-01-01 00:00:00

abstract：:We set out to show that the assumption is incorrect that continuous treatment with cyclosporin is necessary in psoriasis, as this tenet forms a basis for current recommended treatment regimens. Sixty patients with mild to moderate plaque psoriasis were allocated at random to treatment with oral cyclosporin 5 mg/kg/day...

journal_title：Acta dermato-venereologica

authors： Levell NJ,Shuster S,Munro CS,Friedmann PS

更新日期：1995-01-01 00:00:00

abstract：:Gold sodium thiosulfate, inserted in the patch test standard series, gives a surprisingly high yield of positive reactions, about 10% of tested eczema patients, but with a low degree of clinical relevance. A histopathological study on patch test reactions was carried out in patients selected because of a combined cont...

journal_title：Acta dermato-venereologica

authors： Möller H,Larsson A,Björkner B,Bruze M

更新日期：1994-11-01 00:00:00

abstract：:A patient with a Buschke-Loewenstein tumour associated with human papillomavirus type 6/11 is reported. He was intralesionally treated with human recombinant alpha-2b interferon (9 x 10(6) IU/day) three times weekly. The tumour completely disappeared within 5 months of continuous treatment which was well tolerated. Si...

journal_title：Acta dermato-venereologica

authors： Tsambaos D,Monastirli A,Kapranos N,Georgiou S,Pasmatzi E,Berger H

更新日期：1994-11-01 00:00:00